![]() ![]() VROs provide not only a suitable niche to concentrate essential viral and host factors for efficient viral RNA synthesis, but also a protective environment to the double-stranded RNA (dsRNA) replication intermediates from cellular dsRNA nucleases and sensors, e.g., the toll-like receptor 3 (TLR3), RNA helicase RIG-I, MDA-5, dsRNA-dependent protein kinase R (PKR), and Dicer (or Dicer-like, DCL). ![]() VROs are confined membranous compartments that are remodeled by viral replication-associated proteins from the endomembrane, e.g., the endoplasmic reticulum (ER) and the outer membrane of endosomes, mitochondria, peroxisomes, and chloroplasts. We are looking forward to introducing a new Helix to a whole new generation.The replication of positive-sense single-stranded RNA (+ssRNA) viruses usually takes place in virus-induced membranous structures called viral replication organelles (VROs). "Despite the current dominance of a few giant, global companies, I believe the future belongs to fast, creative, bold, and unique companies," says Barnard, "And they deserve systems that mirror their attributes. ![]() But, as Barnard says, "The fun factor in designing and building new custom apps with Helix is very important to our clients but, when there are critical operational needs, an app is only fun to the owner if it is also stable." So reliability will inform every upgrade Helix receives. As BGD takes on the upgrade, keeping things fun is a goal that guides them. Atkin said once that beneath all the technical capabilities and program power, Helix has always aimed to be fun to use. The graphical, drag-and-drop, no-code software was originally programmed by Larry Atkin, among others. And BGD will explore options for new Helix add-ons that allow the software to drive mobile apps, communicate and sync with other Helix collections on a network, make automatic backups, communicate via Twilio, and more. Helix will also receive major security upgrades to meet new, heightened data security standards such as CMMC. With a rewritten rapid-application-development-engine or RADE, Helix will transition to an SQL-based back-end. With the addition of a new browser-based client, Helix will finally allow users on any platform to access a Helix Server. After considerable discussion, we'd concluded that Dana Barnard, as a successful entrepreneur and long-time Helix user, was the right person for the job," Numeroff said.Īlready BGD has gathered capital to create a new corporate platform for Helix and will spend the next 18-24 months modernizing the software. Near the end of our discussion, I told him that maybe it was time for him to buy the company! We were searching for the right partner for the future we had envisioned for Helix. A year or so ago, as QSAToolWorks' Gil Numeroff recalls, "Dana and I had a long conversation in which he asked a lot of questions about the QSA team and the future of Helix. The time to share that secret sauce with today's entrepreneurs has come. The ability to quickly build and easily adjust a robust, multi-user, database system has been a major competitive advantage in our many businesses and ventures," says Barnard, "Helix has been a big part of our 'secret sauce' and frankly, Helix has made us a lot of money." "With our small businesses, we are always battling against much larger competitors. An advocate and current user of the software, he was drawn to the empowerment Helix offered his businesses. Illustration by Jonathan Hill.ĭana Barnard, founder of Big Giant Donut, has used Helix to power four different multi-million-dollar manufacturing and technology companies over the past 30 years. With the purchase of the QSA Toolworks' suite of Helix no-code app development software, New Mexico-based Big Giant Donut aims to update the legacy software to meet the hyper-speed and connectivity needs of today's entrepreneurs and enterprise businesses. ![]()
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